furazolidone a highly effective antimicrobial against metronidazole resistant strains of h. pylori

Antimicrobial effectiveness of furazolidone against metronidazole-resistant strains of Helicobacter pylori.

The occurrence of strains resistant to metronidazole is causing failure of the 4-drug regimen for eradication of Helicobacter pylori in the Islamic Republic of Iran. This study compared the in vitro efficacy of furazolidone with metronidazole, clarithromycin, amoxicillin and tetracycline in 70 H. pylori isolates from dyspeptic patients. Of the isolates, 33% were resistant to metronidazole but a...

Antimicrobial Activity of Ketoconazole and Fluconazole against Metronidazole Resistance Strains of Helicobacter pylori: an In Vitro Study

Resistance to drug such as metronidazole is one the commonest causes of treatment failure while eradicating Helicobacter pylori . Considering the safety of ketoconazole and fluconazole and their inhibitory activity on biosynthesis of fatty acids from cholesterol in cell membrane of H.pylori , the idea of their efficacy against H.pylori is raising . The aim of this study is to evaluate suscep...

Investigation of frxA gene mutations in metronidazole resistant Helicobacter pylori strains in Tabriz City

Background: Due to the high rate of Helicobacter pylori infection in our country and its treatment failure, and also because of the high prevalence of antibiotic resistance of this bacterium, evaluating causes of Helicobacter pylori resistance to metronidazole and its effect on the therapeutic course is necessary. Materials and methods: A biopsy sample was obtained from 275 suspected patients r...

Antimicrobial Activity of Ketoconazole and Fluconazole against Metronidazole Resistance Strains of Helicobacter pylori

Resistance to drug such as metronidazole is one the commonest causes of treatment failure while eradicating Helicobacter pylori. Considering the safety of ketoconazole and fluconazole and their inhibitory activity on biosynthesis of fatty acids from cholesterol in cell membrane of H.pylori, the idea of their efficacy against H.pylori is raising. The aim of this study is to evaluate susceptibili...

Furazolidone- and nitrofurantoin-resistant Helicobacter pylori: prevalence and role of genes involved in metronidazole resistance.

The prevalence of furazolidone, nitrofurantoin, and metronidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone- and nitrofurantoin-resistant isolates were also metronidazole resistant. rdxA, frxA, and fdxB k...

Antimicrobial effectiveness of ketoconazole against metronidazole-resistant Helicobacter pylori isolates from Iranian dyspeptic patients.